Dr Mihalko is the Professor & J.R. Hyde Chair of Excellence in the Campbell Clinic, Department of Orthopaedic Surgery & Biomedical Engineering at the University of Tennessee Health Science Center. He serves as the program chair of the joint graduate program in Biomedical Engineering with the University of Memphis as well as the Chair of the Department of Orthopaedic Surgery Methodist LeBonheur Healthcare System in Memphis, Tennessee.

In addition to his clinical practice, he runs a large implant retrieval lab in collaboration with Drexel, Cleveland Clinic and Clemson Universities.

His other research interests include gait studies concerning hip and knee replacements and biomarkers of aseptic and total joint replacement failures. As a clinician-scientist, he has been actively involved in various regulatory committees including the ASTM International F04 committee on medical and surgical devices, and the AAOS Orthopaedic Device Forum.

He is an elected member of both the Knee Society and the Hip Society. Dr Mihalko is currently a Board member of the ORS, AAHKS and is the ISTA BOD President as he is co-organizer of the 2024 meeting in Nashville.